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Inducible Fas-Resistance in B Lymphocytes

  • Thomas L. Rothstein
  • Thomas J. Schneider
  • Ann Marshak-Rothstein
  • Linda C. Foote

Abstract

Activation of B lymphocytes, such as that provided by CD40L, is required for induction of susceptibility to Fas-mediated apoptosis. However, all forms of B cell activation do not promote Fas-sensitivity. Anti-immunoglobulin antibody, and IL-4, produce a state of Fas-resistance in otherwise sensitive (CD40L-stimulated) B cell targets through at least partially distinct signaling pathways. Inducible Fas-resistance may act to thwart B cell deletion mediated by FasL-expressing CD4+ Th1 cells, either prior to or during germinal center formation. This may promote the viability of autoreactive B cells, thereby fostering autoantibody formation as observed in IL-4 overexpressing transgenic mice, with implications for normal- and auto-immunity.

Keywords

Germinal Center Phorbol Myristate Acetate Antigen Receptor Cell Antigen Receptor Germinal Center Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Thomas L. Rothstein
    • 1
    • 2
    • 4
  • Thomas J. Schneider
    • 2
  • Ann Marshak-Rothstein
    • 2
    • 3
  • Linda C. Foote
    • 2
  1. 1.Department of MedicineBoston University Medical CenterBostonUSA
  2. 2.Department of MicrobiologyBoston University Medical CenterBostonUSA
  3. 3.Department of PathologyBoston University Medical CenterBostonUSA
  4. 4.Evans Memorial Department of Clinical ResearchBoston University Medical CenterBostonUSA

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