CD95 (Fas) Ligand
CD95 (Fas/APO-1) is a 45 kD cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (Nagata and Golstein 1995; Itoh et al. 1991; Oehm et al. 1992; Watanabe-Fukunaga et al. 1992a; Smith et al. 1994). Although CD95 is expressed in many tissues including liver, heart, gut, skin and ovaries (Watanabe-Fukunaga et al. 1992b; Leithauser et al. 1993), its major biological role appears to be in the regulation of immune responses (Nagata and Golstein 1995; Cohen and Eisenberg 1992; Vignaux and Golstein, 1994). Lpr mice which lack the ability to express functional CD95 accumulate large numbers of abnormal T and B cells in their peripheral lymphoid organs and develop autoimmune disease (Cohen and Eisenberg 1992; Cohen and Eisenberg 1991; Roths et al. 1984). The abnormal lymphocytes in these mice express markers found on activated lymphocytes and it appears that autoimmunity develops as a result of an inability to eliminate autoreactive T and B cells.
KeywordsSertoli Cell Immune Privilege Kidney Capsule Tumor Necrosis Factor Receptor Superfamily CD95L Expression
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- Brunner, T., Mogil, R.J., LaFace, D., Yoo, N.J., Mahboubi, A., Echeverri, F., Martin, S.J., Force, W.R., Lynch, D.H., Ware, C.F., and Green, D.R. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 373, 441–444.PubMedCrossRefGoogle Scholar
- Chu, J.L., Ramos, P., Rosendorff, A., Nikolic-Zugic, J., Lacy, E., Matsuzawa, A., and Elkon, K.B. 1995. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J. Exp. Med. 181, 393–398.PubMedCrossRefGoogle Scholar
- Duke, R.C. 1992. Apoptosis in cytotoxic T cells and their targets. Sem. Immunol. 4, 407–412.Google Scholar
- Duke, R.C. and Cohen, J.J. 1992. Cell death and apoptosis. In: Current Protocols in Immunology Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., editors. Greene Publishing Associates, Brooklyn NY, pp. 3.17.1–3.17.16.Google Scholar
- Leithauser, F., Dhein, J., Mechtersheimer, G., Koretz, K., Bruderlein, S., Henne, C., Schmidt, A., Debatin, K.M., Krammer, P.H., and Moller, P. 1993. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest. 69, 415–429.PubMedGoogle Scholar
- Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., Trauth, B.C., Ponsting, H. and Krammer, P.H. 1992. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J. Biol. Chem. 267, 10709–10715.PubMedGoogle Scholar