Taking Out the Immune Response
Since the discovery of Fas (Apo-1/CD95) and its ligand (FasL), the rapid and profound apoptosis triggered by this receptor has held the imagination of researchers in the areas of cell biology and immunology. Antibodies to Fas are potent inducers of apoptosis in many different cell types (Yonehara et al., 1989, Trauth et al., 1989, Owen-Schaub et al., 1992), and the mechanism of this effect is the subject of extensive research (and some controversy). This overview, however, will deal with a different aspect of Fas-mediated apoptosis: its role in the regulation of immune responses.
KeywordsFasL Expression Corneal Allograft Anterior Chamber Associate Immune Deviation Cell Receptor Transgenic Mouse Privileged Tissue
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