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Molecular Mechanisms of T Lymphocyte Apoptosis Mediated by CD3

  • Dexian Zheng
  • Yanxin Liu
  • Yong Zheng
  • Ying Liu
  • Shilian Liu
  • Baoping Wang
  • Markus Metzger
  • Emiko Mizoguchi
  • Cox Terhorst

Abstract

Apoptosis or programmed cell death has been recently known as an very important biological phenomenon in development, differentiation and cellular homeostasis and constant size of organs of multicellular organisms. Lymphoid system is one of the best examples to demonstrate that apoptosis exists all the way through the lives of T and B cells. The T cell repertoire consists of an extremely diverse population of surface receptors (TCRα/β or TCRγ/δ) which participate in highly specific responses to different antigens and mediate antigen stimulation signals. Variable TCRα/β and TCRγ/δ receptors are associated with invariable CD3γ, δ, ε and ζ proteins, thus forming the TCR/CD3 complex.

Keywords

Transgenic Mouse Cytoplasmic Tail Spontaneous Apoptosis Lymphocyte Apoptosis Propidium Iodine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Dexian Zheng
    • 1
  • Yanxin Liu
    • 1
  • Yong Zheng
    • 1
  • Ying Liu
    • 1
  • Shilian Liu
    • 1
  • Baoping Wang
    • 2
  • Markus Metzger
    • 2
  • Emiko Mizoguchi
    • 2
  • Cox Terhorst
    • 2
  1. 1.Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina
  2. 2.Harvard Medical SchoolBostonUSA

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