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Vaccine Design pp 181-185 | Cite as

Protection Against Tuberculosis by Plasmid DNA

  • R. E. Tascon
  • M. J. Colston
  • E. Stavropoulos
  • S. Ragno
  • D. Gregory
  • D. B. Lowrie
Chapter
Part of the NATO ASI Series book series (NSSA, volume 293)

Abstract

The availability of cloned mycobacterial genes and suitable vectors for expression in mammalian cells has now opened a new avenue in which individual mycobacterial protein antigens can be tested for their ability to confer protective immunity. Expression of protection against mycobacteria is largely a function of antigen specific CD4 and cytotoxic CD8 T cells. We have found that intramuscular injection of plasmid DNA expressing several mycobacterial immunodominant genes can induce both T cell populations and confer protection equivalent to BCG, suggesting that this approach may lead to a new vaccine.

Keywords

Hsp65 Gene Tuberculosis H37Rv Mycobacterial Antigen Immune Spleen Cell Mycobacterial Hsp65 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • R. E. Tascon
    • 1
  • M. J. Colston
    • 1
  • E. Stavropoulos
    • 1
  • S. Ragno
    • 1
  • D. Gregory
    • 1
  • D. B. Lowrie
    • 1
  1. 1.Division of Mycobacterial ResearchNational Institute for Medical ResearchLondonUK

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