Vascular Regulation at Sub Millimeter Range
The idea that electrical activity is coupled to microvascular changes is not new. Already a century ago, Roy and Sherrington (1890) postulated that “the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity”. Later studies have indeed demonstrated that there is a strong coupling between neuronal activity, local metabolic activity, and blood flow (Kety et al., 1955; Lassen and Ingvar 1961; Sokoloff, 1977; Raichle et al., 1983; Fox et al., 1986). Modern neuroimaging techniques have used signals that originate from metabolic activity or vascular response because the monitoring and precise localization of such signals sources is often better than those which originate directly from electrical activity.
KeywordsMapping Signal Imaging Spectroscopy Vascular Regulation Intrinsic Signal Intrinsic Optical Signal
Unable to display preview. Download preview PDF.
- Hill DK, Keynes RD (1949), Opacity changes in stimulated nerve, J. Physiol 108:278–281.Google Scholar
- Jobsis FF, Keizer JH, LaManna JC, Rosental MJ (1977), Reflectance spectrophotometry of cytochrome aa3 in vivo. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 43:858–872.Google Scholar
- LaManna JC, Sick TJ, Pikarsky SM, Rosenthal M (1987), Detection of an oxydizable fraction of cytochrome oxidase in intact rat brain, Am. J. Physiol. 253:477–483.Google Scholar
- Lubbers DW (1973), Spectrophotometric examination of tissue oxygenation, Oxygen Transport to Tissue 37A: 45–54.Google Scholar
- Malonek D. and Grinvald A. (1995), D. Malonek and A. Grinvald, 1995: Local autoregulation of cerebral blood flow and blood volume following natural stimulation revealed by Optical Imaging and Spectroscopy of Hbo2 and rhb. Int. Sym. on Cereb. Blood Flow Metab. 17.Google Scholar
- Raichle ME, Martin WRW, Herscovitz P, Minton MA, Markham JJ (1983), Brain blood flow measured with intravenous H2(15)0. II. Implementation and validation, J. Nucl. Med. 24(9):790–798.Google Scholar
- Roy C, Sherrington C (1890), On the regulation of the blood supply of the brain, J. Physiol., 11:85–108.Google Scholar