Vascular Regulation at Sub Millimeter Range

Sources of Intrinsic Signals for High Resolution Optical Imaging
  • Dov Malonek
  • Amiram Grinvald
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)


The idea that electrical activity is coupled to microvascular changes is not new. Already a century ago, Roy and Sherrington (1890) postulated that “the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity”. Later studies have indeed demonstrated that there is a strong coupling between neuronal activity, local metabolic activity, and blood flow (Kety et al., 1955; Lassen and Ingvar 1961; Sokoloff, 1977; Raichle et al., 1983; Fox et al., 1986). Modern neuroimaging techniques have used signals that originate from metabolic activity or vascular response because the monitoring and precise localization of such signals sources is often better than those which originate directly from electrical activity.


Mapping Signal Imaging Spectroscopy Vascular Regulation Intrinsic Signal Intrinsic Optical Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Dov Malonek
    • 1
  • Amiram Grinvald
    • 1
  1. 1.Department of Neurobiology, The Center for Research of Higher Brain FunctionsThe Weizmann Institute of ScienceRehovotIsrael

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