Uncoupling of Absolute CBF to Neural Activity
Since Roy and Sherrington (1890) described that neural activity would regulate blood supply to the brain, it has been widely accepted that neural activation will increase cerebral blood flow (CBF). Lassen and Munck (1955) first demonstrated the regional change of CBF at the cortical areas using radioisotopes. The recent development of technology, e.g. positron emission tomography (PET), has allowed us to measure quantitative CBF at every cubic centimeter of the brain. However, most of psychophysiological brain mapping studies mainly utilize the topographic information to delineate CBF change by canceling out quantitative information of CBF in the process of the statistical analysis to evaluate regional CBF change relating to the neural activity (Friston et al. 1990).
KeywordsCerebral Blood Flow Absolute Scale Oxygen Extraction Fraction Cerebral Blood Flow Change Global Cerebral Blood Flow
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