The question of a coupling between neuronal function, metabolism and blood flow and how it is mediatied has been discussed and investigated since more than a century. Mainly, methods which allow to measure signals related to cerebral blood flow have dominated in this kind of analysis. The possibility to quantify local metabolism in the brain has enlarged our knowledge. However, it soon became evident that functional activation in the brain may not be completely described under all conditions by the clssical order of events in which neural activation induces an increase in brain metabolism which results in an increased in cerebral blood flow. Therefore, it has become a matter of dispute, whether or not metabolism and blood flow in the brain are tightly coupled under physiological conditions with the consequence that coupling is disturbed only under extreme conditions like cerebral ischemia or brain damage.
KeywordsNitric Oxide Blood Flow Cerebral Blood Flow Neuronal Activity Capillary Density
Unable to display preview. Download preview PDF.
- Dirnagl, U., Niwa, K., Lindauer, U., and Villringer, A., 1994, Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am. J. Physiol. 267:H296–301.Google Scholar
- Klein, B., Kuschinsky, W., Schröck, H., and Vetterlein, F., 1986, Interdependency of local capillary density, blood flow and metabolism in the rat brain. Am. J. Physiol. 251:H1333–1340.Google Scholar
- Ko, K.R., Ngai, A.C., and Winn, H.R., 1990, Role of adenosine in regulation of regional cerebral blood flow in sensory cortex. Am. J. Physiol. 259:H1703–1708.Google Scholar
- Kuschinsky, W., and Wahl, M., 1978, Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol. Rev. 58:656–689.Google Scholar
- Kuschinsky, W., 1982, Role of hydrogen ions in regulation of cerebral blood flow and other regional flows. Adv. Microcirc., Karger Basel, 11:1–19.Google Scholar
- Kuschinsky, W., and Paulson, O.B., 1992, Capillary circulation in the brain. Cerebrovasc. Brain Metab. Rev. 4:261–286.Google Scholar
- Lund Madsen, P., Hasselbaich, S.G., Hagemann, L.P., Olsen, K.S., Bülow, J., Holm, S., Wildschiodtz, G., Paulson, O.B., and Lassen, N.A., 1995, Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: Evidence obtained with the Kety-Schmidt technique. J. Cereb. Blood Flow Metab. 15:485–491.CrossRefGoogle Scholar
- Schröck, H., and Kuschinsky, W., 1988, Cerebral blood flow, glucose use and CBF ionic regulation in the potassium depleted rat. Am. J. Physiol. 254:H250–257.Google Scholar
- Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O., and Shinohara, M., 1977, The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897–916.CrossRefGoogle Scholar
- Waschke, K.F., Riedel, M, Albrecht, D.M., van Ackern, K., and Kuschinsky, W., 1994, Autoradiographic determination of regional cerebral blood flow and metabolism in conscious rats after fluid resuscitation from hemorrhage with a hemoglobin-based oxygen carrier. Br. J. Anesth. 73:522–528.CrossRefGoogle Scholar