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Assessment of Local Brain Activation

A Simultaneous PET and Near-Infrared Spectroscopy Study
  • Kersten Villringer
  • Satoshi Minoshima
  • Christoph Hock
  • Hellmuth Obrig
  • Sibylle Ziegler
  • Ulrich Dirnagl
  • Markus Schwaiger
  • Arno Villringer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)

Abstract

In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously. Changes in [oxy-Hb], [deoxy-Hb] and [total-Hb] as measured by NIRS over the left forehead were compared to measurements of cerebral blood flow by PET during rest and during performance of a calculation task and a Stroop task.

When a penetration depth of near-infrared light of 0.9 cm into the brain cortex was assumed, a statistically significant correlation between changes in CBF and changes in [total-Hb] was found. These data confirm the validity of NIRS measurements in human adults.

Keywords

Positron Emission Tomography Cerebral Blood Flow Stroop Task Calculation Task NIRS Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kersten Villringer
    • 1
  • Satoshi Minoshima
    • 2
  • Christoph Hock
    • 3
  • Hellmuth Obrig
    • 4
  • Sibylle Ziegler
    • 5
  • Ulrich Dirnagl
    • 4
  • Markus Schwaiger
    • 5
  • Arno Villringer
    • 4
  1. 1.Department of RadiologyBenjamin-Franklin HospitalBerlinGermany
  2. 2.Division of Nuclear Medicine, Department of Internal MedicineThe University of Michigan, Medical CenterAnn ArborUSA
  3. 3.Department of PsychiatryUniversity of BaselBaselSwitzerland
  4. 4.Department of Neurology, CharitéHumboldt-UniversityBerlinGermany
  5. 5.Department of Nuclear Medicine, Klinikum Rechts der IsarTechnische Universität MünchenMünchenGermany

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