Red Blood Cells as a Glucocorticoids Delivery System
Macrophages are long-lived phagocytes with both cytocidal and microbicidal activity. These cells exist in a relatively quiescent basal state and also in “stimulated” or “activated” states. Activation of macrophages occurs by different stimuli (cytokines, bacterial lipopolysaccharide, etc.) and results in increased production of reactive oxygen metabolites and nitric oxide, increased phagocytic uptake, and release of many cytokines including IL-1, IL-6, TNF-α and growth factors (M-CSF, G-CSF). Upon activation macrophages also release lipid mediators (prostaglandins and leukotrienes) and numerous enzymes (1).
KeywordsHuman Erythrocyte Latex Bead Glucocorticoid Hormone Malignant Histiocytosis Cytofluorimetric Analysis
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