Thymoma—Prognostic Factors and Outcome

  • Kristina Friström
  • A. Cervin
  • J. P. Enoksson
  • M. Albertsson
  • L. Johansson


Thymomas are common mediastinal lesions, especially in association with myasthenia gravis. Here we report a material of 67 patients treated for thymoma. The incidence of myasthenia gravis was 43%. There was no difference in relapse-free survival for patients with or without myasthenia gravis, nor taken into concideration autoimmune diseases in general. Twenty-seven per cent had no symptoms of their tumor and this group fared better regarding relapse-free survival during a follow-up of nine years. There was no significant difference regarding survival neither for age, nor sex, however a significant difference was noted in relation to stage I–IV. Eighty-two per cent were macroscopically radically resected and 28% had some kind of further treatment, and in the latter group survival was significantly lower.

The patients are followed up to ten years. Twenty-one patients have passed away. Forty-five patients are alive with no evidence of disease. One patient is alive with disease.

Thymomas are often malignant (about 25%), but they rarely metastasize. Their malignant potential is demonstrated by a direct invasion of the lung, pericardium, blood vessels, and lymphatics.


Merkel Cell Carcinoma Thymic Carcinoma Mediastinal Tumor Polymyalgia Rheumatica Invasive Thymoma 


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kristina Friström
    • 1
  • A. Cervin
    • 1
  • J. P. Enoksson
    • 1
  • M. Albertsson
    • 1
  • L. Johansson
    • 1
  1. 1.Departments of Oncology and PathologyUniversity HospitalLundSweden

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