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Onset of Myasthenia Gravis after Thymectomy for Thymoma

  • F. Tezzon
  • M. G. Passarin
  • T. Zanoni
  • G. Furlan
  • G. Ferrari

Abstract

Myasthenia Gravis (M.G.) is an autoimmune disease with antibodies directed against the skeletal muscle acetylcholine receptor (AChR) (4). Although the production of AChR antibodies is due to B lymphocytes, there is evidence that T cells are involved in the autoantibody response. (4, 18).

Keywords

Thymus Gland Myoid Cell Autoantibody Response Myasthenic Patient AChR Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Beghi E, Antozzi C, Batocchi AP, Cornelio F, Cosi V, Evoli A, Lombardi M, Mantegazza R, Monticelli M L, Piccolo G, Tonali P, Trevisan D, Zarrelli M. 1991. Prognosis of Myasthenia gravis: a multicenter followup study of 844 patients. J Neurol Sci. 106:213–220.CrossRefPubMedGoogle Scholar
  2. 2.
    Blalock A, Mason MF, Morgan HJ, Raven SS. 1939. Myasthenia gravis and tumors of the thymic region: report of a case in which the tumor was removed. Ann Surg.l 10:544–561.CrossRefGoogle Scholar
  3. 3.
    Castleman B. 1966. The pathology of the thymus gland in Myasthenia Gravis. Ann N Y Acad Sci. 135:496–505.CrossRefPubMedGoogle Scholar
  4. 4.
    Drachman D B. 1994. Myasthenia Gravis. N Engl J Med. 330:1797–1810.CrossRefPubMedGoogle Scholar
  5. 5.
    Durelli L, Maggi G, Casadio C, Ferri R, Rendine S, Bergamini L. 1991. Actuarial analysis of the occurrence of remissions following thymectomy for Myasthenia Gravis in 400 patients. J Neurol Neurosurg Psych. 54:406–411.CrossRefGoogle Scholar
  6. 6.
    Hassel B, Gilhus NE, Aarli JA, Skogen OR. 1992. Fulminant Myasthenia Gravis and polymyositis after thymectomy for thymoma. 85:63–65.Google Scholar
  7. 7.
    Holfeld R.1980. Myasthenia Gravis and thymoma: paraneoplastic failure of neuromuscular transmission. Lab Invest. 62:241–243.Google Scholar
  8. 8.
    Kuroda Y, Ken-ichiro O, Neshige R, Shibasaki H. 1993. Exacerbation of Myasthenia Gravis after removal of a thymoma having a membrane phenotype of suppressor T cells. Ann Neurol. 15:400–402.CrossRefGoogle Scholar
  9. 9.
    Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E. 1991. Thymoma: results of 241 operated cases. Ann Thorac Surg 51:152–156.CrossRefPubMedGoogle Scholar
  10. 10.
    Muller-Hermelink HK, Marx A, Gender K, Kirchner T. 1993. The pathological basis of thymoma-associated Myasthenia Gravis. Ann N Y Acad Sci. 681:56–65.CrossRefPubMedGoogle Scholar
  11. 11.
    Namba T, Brunner NG, Grob D. 1978. Myasthenia Gravis in patients with thymoma with particular reference to onset after thymectomy. Medicine. 57:411–432.CrossRefPubMedGoogle Scholar
  12. 12.
    Neau P, Robert R, Pourrat O, Patte F, Gil R, Lefevre J P. 1988. Myasthenic survenant après ablation d’un thymome. La Presse Med. 17:391–392.Google Scholar
  13. 13.
    Osserman K E, Genkins G. 1971. Studies in Myasthenia Gravis: review of a twenty-year experience in over 1200 patients. Mt Sinai J Med. 38:497–537.PubMedGoogle Scholar
  14. 14.
    Palmisani MT, Evoli A, Batocchi AP, Provenzano C, Tonali P. 1993. Myasthenia Gravis associated with thymoma: clinical characteristic and long term outcome. Eur Neurol. 34:78–82.CrossRefGoogle Scholar
  15. 15.
    Papatestas AE, Genkins G, Kornfeld P, Eisenkraft JB, Fagerstrom RP, Pozner J, Aufses A. H. 1987. Effects of thymectomy in Myasthenia Gravis. Ann Surg. 206:79–88.CrossRefPubMedGoogle Scholar
  16. 16.
    Sommer N, Willcox N, Harcourt GC, Newsom-Davis J. 1990 Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells. Ann Neurol. 28:312–319.CrossRefPubMedGoogle Scholar
  17. 17.
    Somnier F E. 1994. Exacerbation of Myasthenia Gravis after removal of thymomas. Acta Neurol Scand. 90:56–66.CrossRefPubMedGoogle Scholar
  18. 18.
    Wekerle H. 1993. The Thymus in Myasthenia Gravis. Ann N Y Acad Sci. 681:47–55.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • F. Tezzon
    • 1
  • M. G. Passarin
    • 1
  • T. Zanoni
    • 1
  • G. Furlan
    • 2
  • G. Ferrari
    • 1
  1. 1.Department of NeurologyOspedale Civile MaggioreItaly
  2. 2.Department of Thoracic SurgeryOspedale Civile MaggioreVeronaItaly

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