Myasthenia Gravis with Thymoma and Fas Antigen
Fas is a 45 kD transmembrane protein which is able to induce apoptosis, belongs to the tumor necrosis factor-receptor (TNF-R) super family1 and was expressed in a variety of epithelial cells2. Fas ligand (FasL) is a 40 kD membrane protein and one of the TNF family3. Fas-L induces apoptosis to the cell having Fas antigen after binding to Fas. In the thymus, Fas is present and known to work on negative selection by deletion of autoreactive T-cell clones4. In patients with myasthenia gravis (MG) and thymoma, the value of anti-acetylcholine receptor (AChR) antibody is often found high5. The pathogenesis of the anti-AChR-antibody has not been fully elucidated. The messenger RNA of AChR-αsubunit was reported in cultured thymoma cells6. In the mechanism producing anti-AChR autoantibody, abnormal Fas-FasL system may have a role. The purpose of the present study is to find the localization and to detect function of Fas in thymomas of patients with MG.
KeywordsCell Death Detection TUNEL Method Ofinternal Medicine Paraffin Embed Section Medullary Epithelial Cell
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