Accessory Molecule Expression in Human Thymomas and Thymus
Paraneoplastic MG is probably caused by sensitisation of T-cells to muscle-like epitopes presented on the neoplastic epithelial cells. Accessory molecules on antigen-presenting cells and T-cells are important for the outcome of the immunisation process. In this study, cryostat sections from 13 thymomas (11 with MG, 2 without; 10 non-invasive, 3 invasive; 3 spindle-cell, 10 polygonal-cell thymomas) and 6 normal thymuses from children were examined for the accessory molecules ICAM-1, VCAM-1, LFA-3 and CD28 using commercially available mouse monoclonal antibodies and immunoperoxidase staining.
KeywordsClonal Deletion Accessory Molecule Thymic Epithelial Tumour Normal Thymus Neoplastic Epithelial Cell
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