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Analysis of a Murine Thymic Carcinogenesis Model Induced by the Expression of Large T of SV40

  • Thierry Molina
  • Lucile Miquerol
  • Geoffroy de Ribbains
  • Mounir Bouleksibat
  • Catherine Martinon
  • Sophie Ezine
  • Alain Vandewalle
  • Jacques Diebold
  • Axel Kahn

Abstract

Large T of SV40 is a viral protein involved in the lytic cycle of its natural host, the monkey, but has transforming properties after transfection in some murine and human cell lines. The targeting of this oncogene under the control of tissue-specific promotors in transgenic mice led to the creation of in vivo models of tumors: hepatocarcinomas, lymphomas, neuroendocrine carcinomas, choroid plexus carcinomas, thymic hyperplasia, hypoplasia, thymomas. The oncogenic function of this protein is mainly linked to the sequestration of tumor suppressor gene products, namely p53 and Rb.

Keywords

Neuroendocrine Carcinoma Thymic Carcinoma Lytic Cycle Thymic Hyperplasia Choroid Plexus Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Thierry Molina
    • 1
  • Lucile Miquerol
    • 2
  • Geoffroy de Ribbains
    • 2
  • Mounir Bouleksibat
    • 1
  • Catherine Martinon
    • 3
  • Sophie Ezine
    • 3
  • Alain Vandewalle
    • 4
  • Jacques Diebold
    • 1
  • Axel Kahn
    • 2
  1. 1.Faculté Broussais-Hôtel-DieuLaboratoire Universitaire de Recherches en HistopathologieParisFrance
  2. 2.ICGMUnité INSERM U 129ParisFrance
  3. 3.Faculté NeckerUnité INSERM U 345ParisFrance
  4. 4.Faculté BichatUnité INSERM U 246ParisFrance

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