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Neuroendocrine Differentiation in Thymic Epithelial Tumors

Immunohistochemical Studies
  • Tsunekazu Hishima
  • Masashi Fukayama
  • Yukiko Hayashi
  • Takeshi Fujii
  • Katsumi Arai
  • Yumiko Shiozawa
  • Nobuaki Funata
  • Morio Koike

Abstract

The classification of thymic epithelial tumors is an issue of some controversy1. Müller-Helmelink et al. proposed a scheme based on the morphological differences of normal thymic epithelial cells: i.e., cortical or medullary2. While their proposed classification is theoretical, it has been successfully applied to thymic epithelial tumors without cellular atypia. However, the morphology of thymic epithelial tumors with cellular atypia is considerably different than that of their normal counterparts. Recently we found that the CD5 molecule, which is authentically expressed in T-lymphocytes and some B-lymphocytes, is expressed in thymic carcinoma and atypical thymoma3.

Keywords

Thymic Carcinoma Thymic Epithelial Cell Neuroendocrine Differentiation Thymic Tumor Thymic Epithelial Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Müller-Hermelink HK, Marks A, Kirchner TH: Advances in the diagnosis and classification of thymic epithelial tumours. Recent advances in histopathology. Edited by Anthony PP and MacSween RM. Churchill Livingstone, 1994: pp49-72Google Scholar
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    Hishima T, Fukayama M, Fujisawa M, Hayashi Y, Arai K, Funata N, Koike M: CD5 expression in thymic carinoma. Am J Pathol 1994, 145:268–275.PubMedGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Tsunekazu Hishima
    • 1
  • Masashi Fukayama
    • 2
  • Yukiko Hayashi
    • 1
  • Takeshi Fujii
    • 2
  • Katsumi Arai
    • 1
  • Yumiko Shiozawa
    • 1
  • Nobuaki Funata
    • 1
  • Morio Koike
    • 1
  1. 1.Department of PathologyTokyo Metropolitan Komagome HospitalBunkyo-ku, TokyoJapan
  2. 2.Department of PathologyJichi Medical SchoolTochigiJapan

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