The Development of Methods to Assess the Temporal Relationship of Depressive and Psychotic Symptoms in Schizophrenia

  • Michael Foster Green
  • Keith H. Nuechterlein
  • Jim Mintz
  • Joseph Ventura
Conference paper


Depression presents a serious problem for many schizophrenic patients. However, little is known about the nature and course of this depression. Van Putten and May (1) suggested that some of the observed depression in schizophrenia may be a drug-induced akinesia syndrome. It has been proposed that depression in schizophrenia can be a “reactive” depression to the disruptive effects of the psychotic episode (2). McGlashan (3) introduced the term “aphanisis” to describe the residual schizophrenic defect state that might be confused with depression. It has also been argued that postpsychotic depression actually begins concurrent with psychotic symptoms but that the depressive symptoms are not noticeable until the florid symptoms begin to remit (4,5). In addition, Herz and Melville (6) demonstrated that depression is commonly reported in the prodromal period, suggesting that “prepsychotic” or prodromal depression may be an addition relevant type of depression.


Depressive Symptom Psychotic Symptom Time Series Analysis Depressive Episode Categorical Analysis 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Michael Foster Green
    • 1
  • Keith H. Nuechterlein
    • 1
  • Jim Mintz
    • 1
  • Joseph Ventura
    • 1
  1. 1.Department of Psychiatry and Biobehavioral SciencesUniversity of CaliforniaLos AngelesUSA

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