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Dendritic Cells in Fundamental and Clinical Immunology pp 551–569Cite as

Dendritic Cell Based Therapy of Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 417))

Abstract

The recent identification of techniques both in the mouse and in man to culture dendritic cells which could be adoptively trasnferred for therapy have opened new avenues of research. We have applied both synthetic and natural or acid eluted peptides from the tumor cell surface in order to elicit effective antitumor responses in vivo and in vitro in murine tumor models as well as in vivo in human preclinical trials. Based on these studies, we will soon initiate a human clinical trial utilizing human dendritic cells pulsed with synthetic melanoma derived peptides presented by HLA-A2. The delivery of genes into human dendritic cells to constitutively express cytokines, costimulatory molecules or tumor antigens represents another potential approach to the development of dendritic cell based therapies.

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Authors and Affiliations

  1. Departments of Surgery,and Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261, USA

    Michael T. Lotze, Michael Shurin, Ian Davis, Andrew Amoscato & Walter J. Storkus

  2. Biological Therapeutics Division, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15261, USA

    Michael T. Lotze, Michael Shurin, Ian Davis, Andrew Amoscato & Walter J. Storkus

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  1. Michael T. Lotze
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  2. Michael Shurin
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  1. CNR Center of Cytopharmacology, University of Milan, Milan, Italy

    Paola Ricciardi-Castagnoli

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Lotze, M.T., Shurin, M., Davis, I., Amoscato, A., Storkus, W.J. (1997). Dendritic Cell Based Therapy of Cancer. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_91

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