Dendritic Cells Induce Immunity to Cutaneous Leishmaniasis in Mice
In humans, the protozoan parasite Leishmania major produces a range of cutaneous disease manifestations. The skin lesions vary from small papules to non-ulcerated plaques to large ulcers with defined, raised edges. Satellite lesions are common. L. major infections are caused by introduction of parasites into the skin during a blood meal of an infected sandfly; they heal spontaneously after a few months to more than a year and are associated with severe scarring. In mammalian hosts, the parasites are obligatory intracellular and reside within macrophages and dendritic cells, which not only serve as a habitat for the parasite, but also fulfil antigen-presenting and antimicrobial effector functions.1,2
KeywordsDendritic Cell Major Histocompatibility Complex Class Cutaneous Leishmaniasis Mannose Receptor Leishmania Infection
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