Positive and Negative Regulation of Dendritic Cell Function by Lipopolysaccharide in Vivo
There is evidence that induction of primary immune responses in vitro and in vivo relies on the presentation of antigen by dendritic cells1. The unique property of DC to sensitize naive T lymphocytes may depend on a specialization of function over time that results in a reciprocal regulation of the capacity to process antigens and to activate T cells. Fresh DC process antigens and generate high levels of peptides/MHC complexes, whereas cultured DC have lost this capacity but have gained the property to prime T lymphocytes. This process of maturation occurs spontaneously in culture and correlates with increased expression of class II, B7-1 and B7-2 costimulatory molecules2–6.
KeywordsDendritic Cell Marginal Zone SCID Mouse Cell Area White Pulp
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