Absence of Follicular Dendritic Cells (FDC) in Mutant Mice with Deficient TNF/Lymphotoxin (LT) Signaling
FDC occur as clusters in the B cell areas (follicles) of lymph nodes, spleen, tonsil and Peyers patches. Anatomically these clusters appear as a locally specialized compartment of a cellular meshwork that spans the secondary lymphoid tissues. FDC are mostly considered to differentiate from the fibroblast-like cells forming that meshwork (l-6). However there is experimental support for the alternative view that FDC might originate from the bone marrow (2,7,8). It is possible to distinguish FDC by ultrastructural criteria from other cells of the reticular meshwork (4,6,9). Identification by light microscopy requires specific markers, e. g. antibodies against complement receptors (CR) (10). The monoclonal antibody FDC-M1 detects FDC in the mouse (11). Binding of immune complexes, e. g. peroxidase-anti-peroxidase, in vivo as well as in tissue sections constitutes a further criterion for identification of FDC (12).
KeywordsGerminal Center Complement Receptor Follicular Dendritic Cell Severe Combine Immunodeficiency Postnatal Development
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- 10.Kinoshita, T., J. Takeda, K. Hong, H. Kozono, H. Sakai, and K. Inoue. 1988. Monoclonal antibodies to mouse complement receptor type 1 (CRI). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative. Jlmmunol 140: 3066–3072.Google Scholar
- 15.Kosco-Vilbois, M. H., D. Gray, D. Scheidegger, and M. Julius. 1993. Follicular dendritic cells help resting B cells to become effective antigen-presenting cells: induction of B7/BB I and upregulation of major histocompatibility complex class II molecules. J Exp Med 178: 2055–2066.PubMedCrossRefGoogle Scholar