Infection of Human Dendritic Cells by Measles Virus Induces Immune Suppression

  • Dominique Kaiserlian
  • Isabelle Grosjean
  • Christophe Caux
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Measles is characterized by lifelong immunity and a transient immunosuppression which, in developing countries, is responsible for a high morbidity and a high mortality consecutive to secondary infections. Strickingly, the immune suppression is coincident with MV-specific immunity and continues for several weeks after apparent recovery from measles. The immune suppression is characterized by the loss of delayed-type hypersensitivity skin test responses to recall antigens, such as tuberculin, and by the inhibition of antibody production and cellular immune responses to new antigens (1).


Immune Suppression Measle Virus Human Dendritic Cell Measle Virus Infect Skin Test Response 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Dominique Kaiserlian
    • 1
  • Isabelle Grosjean
    • 1
  • Christophe Caux
    • 2
  1. 1.INSERM Unit 404 “Immunité et Vaccination”Institut Pasteur de Lyon Avenue Tony GamierLyon CX 07France
  2. 2.Schering-PloughDardillyFrance

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