The Role of Dendritic Cells in the Transport of HIV to Lymph Nodes Analysed in Mouse
The migration route of dendritic cells (DC) from peripheral tissues to lymph nodes (1) and their capacity to pass HIV infection to T cells (2–4) support a critical role for DC in the early events of HIV infection. It is assumed, but not yet demonstrated, that DC are the first HIV target cells in the mucosa and that their migration to draining lymph nodes will result in the transmission of HIV to T lymphocytes. Interestingly, this can be studied in a murine model, although murine cells are not susceptible to HIV infection. Indeed, (i) murine DC pre-incubated with HIV are able to transfer it to human T lymphocytes as efficiently as human DC (4); (ii) murine DC can be manipulated in vitro, re-injected, and their in vivo migration can be analysed.
KeywordsDendritic Cell Drain Lymph Node Inguinal Lymph Node Mouse Bone Marrow Human Dendritic Cell
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