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Dendritic Cells as Immunogens for Human CTL Responses

  • Armin Bender
  • Mark Sapp
  • Mary Feldman
  • Anita Reddy
  • Robert Seder
  • Gerold Schuler
  • Ralph M. Steinman
  • Nina Bhardwaj
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Summary

The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example, together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.

Keywords

Dendritic Cell Influenza Virus Mature Dendritic Cell Cellular Requirement Fusogenic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Armin Bender
    • 2
  • Mark Sapp
    • 1
  • Mary Feldman
    • 1
  • Anita Reddy
    • 1
  • Robert Seder
    • 3
  • Gerold Schuler
    • 2
  • Ralph M. Steinman
    • 1
  • Nina Bhardwaj
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA
  2. 2.University of ErlangenErlangenGermany
  3. 3.The National Institutes of HealthBethesdaUSA

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