IL-10 Prevents the Generation of Dendritic Cells from CD14+ Blood Monocytes, Promotes the Differentiation to Mature Macrophages and Stimulates Endocytosis of FITC-dextran
Dendritic cells (DC) constitute an heterogeneous system of leukocytes specialized in antigen (Ag) capture, processing and presentation to immunocompetent cells1,2. Their hematopoietic differentiation lineage of DC has not clearly been defined. At least some DC are closely related to the mononuclear phagocyte system, but there is also evidence of DC belonging to a separate differentiation pathway1,2. Recently large quantities of DC have been differentiated from monocyte-enriched PBMC using GM-CSF and IL-43,4. We have demonstrated that IL-4 can be substituted with IL-13, with identical results.
KeywordsDendritic Cell Blood Monocyte Mannose Receptor Mononuclear Phagocyte System Dendritic Cell Differentiation
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