Antigen Presentation and IL-12 Production by Dendritic Cells in Vivo

  • Jean-Charles Guéry
  • Francesco Ria
  • Francesca Galbiati
  • Luciano Adorini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


IL-12 is a key regulatory cytokine produced by APC which drives the development of interferon-γ (IFN-γ)-producing Thl cells and promotes cell-mediated immunity1. The biologically active IL-12 molecule is a covalently linked heterodimer of approximately 75 kDa composed of two chains, p40 and p35 encoded by separate genes2;3.


Dendritic Cell Drain Lymph Node Cell Cognate Interaction Immune Lymph Node Buoyant Density Cell 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jean-Charles Guéry
    • 2
  • Francesco Ria
    • 1
  • Francesca Galbiati
    • 1
  • Luciano Adorini
    • 1
  1. 1.Roche Milano RicercheMilanoItaly
  2. 2.INSERM U28Hôpital PurpanToulouseFrance

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