Langerhans Cells in the TGFβ1 Null Mouse
We recently identified a cell surface protein (gp40) that is homologous to human EpCAM, a putative homophilic adhesion molecule, and that is abundantly expressed by some murine dendritic cells (including Langerhans cells) and in certain epithelia (1). While characterizing various dendritic cells with regard to gp40 expression, we determined that the pleiotropic cytokine TGFβ;1 was uniquely able to induce cell surface expression of gp40 on dendritic cells propagated from murine bone marrow in fetal calf serum- and GM-CSF-supplemented media. To determine whether or not this finding was potentially physiologically significant, we studied Langerhans cells in TGFβ1 null mice that had previously been generated and described by Kulkarni, Karlsson and coworkers (2).
KeywordsDendritic Cell Null Mouse Murine Bone Marrow Gp40 Expression Epidermal Sheet
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