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B7-2+ Low Density APCS are as Effective as B7-2 Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo

  • Masanori Niimi
  • Mary-Anne Rawsthorne
  • Peter J. Morris
  • Kathryn J. Wood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

Dendritic cells and small resting B cells are thought to be immunogenic and tolerogenic in the periphery, respectively, as dendritic cells but not resting B cells can provide costimulatory signal(s) (1–7). Fuchs and Matzinger demonstrated that resting B cells but not dendritic cells could induce tolerance to H-Y mismatched skin grafts (8). We have extended this study by comparing the ability of dendritic cells and resting B cells to induce tolerance to cardiac grafts mismatched for miH antigen(s).

Keywords

Skin Graft Costimulatory Signal Operational Tolerance Cardiac Graft John Radcliffe Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Masanori Niimi
    • 1
  • Mary-Anne Rawsthorne
    • 1
  • Peter J. Morris
    • 1
  • Kathryn J. Wood
    • 1
  1. 1.Nuffield Department of SurgeryUniversity of OxfordOxfordUK

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