Abstract
Dendritic cells and small resting B cells are thought to be immunogenic and tolerogenic in the periphery, respectively, as dendritic cells but not resting B cells can provide costimulatory signal(s) (1–7). Fuchs and Matzinger demonstrated that resting B cells but not dendritic cells could induce tolerance to H-Y mismatched skin grafts (8). We have extended this study by comparing the ability of dendritic cells and resting B cells to induce tolerance to cardiac grafts mismatched for miH antigen(s).
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Niimi, M., Rawsthorne, MA., Morris, P.J., Wood, K.J. (1997). B7-2+ Low Density APCS are as Effective as B7-2− Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo . In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_43
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_43
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