Role of Dendritic Cells in Induction of Tolerance and Immunity in Vivo
Despite the recent revolution in understanding the molecular mechanisms of T cell activation, the means by which naive CD4+ T cells become tolerant or immune in response to antigen remains controversial. Evidence from a number of experimental systems has suggested that the process of determining the phenotype (but not the specificity) of immune responses is initiated by APCs1,2. However not only is the precise signalling pathway between APCs and naive T cells still undefined, but the role of each particular type of APC in the initiation of diverse immune responses in vivo is unclear.
KeywordsDendritic Cell Adoptive Transfer Cell Tolerance Double Transgenic Mouse Immunodeficient Host
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- 1.Janeway, C. A. J. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13: 11–16 (1992).Google Scholar
- 5.Duncan, D. D., and Swain, S. L. Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages. Eur. J. Immunol. 24: 2506–2514 (1994).PubMedCrossRefGoogle Scholar
- 9.Goroff, D. K., Holmes, J. M., Basin, H., Nisol, F., and Finkelman, F. D. Polyclonal activation of the murine immune system by an antibody to IgD: XI contribution of membrane IgD cross-linking to the generation of an in vivo polyclonal antibody response. J. Immunol. 146: 18–25 (1991).PubMedGoogle Scholar
- 15.Fulcher, D. A., Lyons, A. B., Korn, S. L., Cook, M. C., Koleda, C., Parish, C., Fazekas de St. Groth, B., and Basten, A. The fate of self-reactive B-cells depends primarily on the degree of antigen receptor engagement and availability of T-cell help. J. Exp. Med. 183: 2313–2328 (1996).PubMedCrossRefGoogle Scholar
- 17.Fazekas de St. Groth, B., Patten, R. A., Ho, W. Y., Rock, E. P., and Davis, M. M. An analysis of T cell receptor-ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis. Academic Press. San Diego. (1992).Google Scholar
- 18.Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., Trent, R. J., and Basten, A. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676–682 (I 988).Google Scholar
- 19.Fazekas de St. Groth, B., Cook, M. C., and Smith, A. L. The role of T cells in the regulation of B cell tolerance. Int. Rev. Immunol. in press (1996).Google Scholar
- 20.Widera, G., Burkly, L. C., Pinkert, C. A., ‘Ringer, E. C., Cowing, C., Palmiter, R. D., Brinster, R. L., and Flavell, R. A. Transgenic mice selectively lacking MHC Class II (1-E) antigen expression on B cells: an in vivo approach to investigate la gene function. Cell 51: 175–187 (1987).Google Scholar
- 22.HayGlass, K. T., Naides, S. J., Scott, C. F. J., Benacerraf, B., and Sy, M.-S. T cell development in B cell-deficient mice. IV. The role of the B cells as antigen-presenting cells in vivo. J. Immunol.:823–829 (1986).Google Scholar
- 25.Liu, Y., Wu, Y., Ramarathinam, L., Guo, Y., Huszar, D., Trounstine, M., and Zhao, M. Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response. lat. Immunol. 7: 1353–1362 (1995).Google Scholar
- 26.Constant, S., Schweitzer, N., West, J., Ranney, P., and Bottomly, K. B lymphocytes can be competent antigen-presenting cells for priming CDC T cells to protein antigens in vivo. J. lnnnunol. 155: 3734–3741 (1995).Google Scholar
- 28.Kurt-Jones, E. A., Llano, D., HayGlass, K. A., Benacerraf, B., Sy, M.-S., and Abbas. A. K. The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice. J. Immunol. 140: 3773 3778 (1988).Google Scholar