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Delivery Systems for Recombinant Methionyl Human Growth

  • Jerome A. Moore
  • Helga Wilking
  • Ann L. Daugherty
Part of the NATO ASI Series book series (NSSA, volume 125)

Abstract

The advent of recombinant DNA technology has lead to an increased interest in convenient, effective pharmaceutical dosage forms for polypeptide drugs. It is well known that there are many obstacles to delivery of these compounds by conventional dosage forms. Large molecular weight, solubility problems, suseptibility to enzymatic degradation, sensitivity to pH and temperature, and short in vivo half life are some of the problems that must be confronted. For drugs with such complex biological activities as most therapeutic polypeptides one of the biggest obstacles to development of delivery systems is lack of information on the mechanism of action of the drug.

Keywords

Dosage Form Bile Salt Cocoa Butter Human Growth Hormone Sodium Salicylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jerome A. Moore
    • 1
  • Helga Wilking
    • 1
  • Ann L. Daugherty
    • 1
  1. 1.Pharmacological SciencesGenentech, Inc.USA

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