Routes of Administration for Polar Compounds of Moderate Molecular Weight with Particular Reference to Analogues of Somatostatin
Somatostatin (SS) is a 14-amino acid peptide with a cystine bridge forming a 12-amino acid ring. SS suppresses the release of many peptide hormones (eg: insulin; glucagon; growth hormone). Interest has centred on its potential use in acromegaly (growth hormone suppression) and diabetes (glucagon suppression). Because of its multiple actions it has been considered necessary to search for analogues with more specific properties.
KeywordsSodium Cromoglycate Horse Radish Peroxidase Depot Effect Nasal Administration Nasal Absorption
Unable to display preview. Download preview PDF.
- Bloom, S.R., Adrian, T.E., Barnes, A.J., Long, R.G., Hanley, J., Mallinson, C.N., Rivier, J.E. and Broen, M.R., 1978, New specific long-acting somatostatin analogues in treatment of pancreatic endocrine tumours, Gastroenterology, 74: 1013.Google Scholar
- Crone, C. and Levitt, D.G., 1984, Capillary permeability to small solutes, Handbook of Physiol., 6: 411.Google Scholar
- Peters, G.E., Hutchinson, L.E.F., Hyde, R., McMartin, C, Metcalfe, S.B. and Sibbons, P.D., 1986a, The effects of sodium 5-methoxysalicylate on macromolecule absorption in a vascularly perfused rat gut preparation in vivo, in preparation.Google Scholar
- Peters, G.E. and Sibbons, P.D., 1984, Macromolecule absorption in a vascularly perfused rat gut preparation in vivo, Second Eur. Cong. Biopharm. and Pharmacokin., 2: 424.Google Scholar
- Veber, D.L. Freidinger, M.R., Schwenk, P.D., Palvedo, W.J. Jr., Holly, F.W., Strachan, R.G., Nutt, R.F., Arison, B.H., Homnick, C., Randall, W.C., Glitzer, M.S., Saperstein, R. and Hirschmann, R., 1981, A potent cyclin hexapeptide analogue of somatostatin, Nature, 292: 55.PubMedCrossRefGoogle Scholar