Advertisement

Intranasal Delivery of the Peptide, Salmon Calcitonin

  • Musetta Hanson
  • G. Gazdick
  • J. Cahill
  • M. Augustine
Part of the NATO ASI Series book series (NSSA, volume 125)

Abstract

Calcitonin is a polypeptide hormone normally secreted by the parafollicular cells of mammalian thyroid glands and by the ultimobronchial gland of birds and fish. The linear sequence of 32 amino acids found in the calcitonin of salmon origin has been synthesized. This synthetic salmon calcitonin (sCT) is currently formulated as a sterile solution for subcutaneous injection in the treatment of Paget’s disease, hypercalcemia, and osteoporosis. Paget’s disease is a disorder characterized by abnormal bone formation and resorption while hypercalcemia is an elevated serum calcium level, and osteoporosis is a loss of bone mass with increased fractures. Treatment calls for daily subcutaneous injections of salmon calcitonin over an extended period. The necessity of this daily injection is bothersome and inconvenient to patients. However, because the drug is a polypeptide subject to digestive degradation, it can not be given orally. Therefore, an alternate route of administration, such as intranasally, is attractive.

Keywords

Serum Calcium Bile Salt Nasal Mucosa Salmon Calcitonin Post Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B’hend, P., Hadron, B., Haldeman, B., Klebb, M., and Luthi, H., 1973, Stimulation of pancreatic secretion in man by secretin snuff, Lancet, i:510.Google Scholar
  2. Felber, J., Aubert, M., and Deguillaume, R., 1969, Administration by nasal spray of an 18 amino acid synthetic polypeptide with corticotrophic action, Experimentia, 25: 1195.CrossRefGoogle Scholar
  3. Hendrick, C. and Gabel, R., 1960, Use of intranasal oxytocin in obsterics, Am. J. Obstet. Gynec., 79: 780.Google Scholar
  4. Hirai, S., Ikenaga, T., and Matsuzana, T., 1978, Nasal absorption of insulin in dogs, Diabetes, 27: 296.CrossRefGoogle Scholar
  5. Hirai, S., Yashiki, T., and Mima, H., 1978, Effect of surfactants on the nasal absorption of insulin in rats, Int. J. Pharm., 9: 165.Google Scholar
  6. Hirai, S., Yashiki, T. and Mina, H., 1978, Mechanism for the enhancement of the nasal absorption of insulin by surfactants, Int. J. Pharm., 9:173.Google Scholar
  7. Hussain, A., Hirai, S., and Bawarshi, R., 1979, Nasal absorption of propranolol in rats, J. Pharm. Sci., 68: 1196.PubMedCrossRefGoogle Scholar
  8. Hussain, A., Foster, T., Hirai, S., Kashihara, T., Batenhorst, R., and Jones, M., 1980, Nasal absorption of propranolol in humans, J. Pharm. Sci., 69: 1240.PubMedCrossRefGoogle Scholar
  9. Hussain, A., Hirai, S., and Bawarshi, R., 1980, Nasal absorption of propranolol from different dosage forms by rats and dogs, J. Pharm. Sci., 69: 1411.PubMedCrossRefGoogle Scholar
  10. Hussain, A., Hirai, S., and Bawarshi, R., 1981, Nasal absorption of natural contraceptive steroids in rats — progesterone absorption, J. Pharm. Sci., 70: 466.PubMedCrossRefGoogle Scholar
  11. Keenan, J., Thompson, J., Chamberlain, M. and Bessir, G., 1971, Prolonged corticotrophic action of a synthetic substituted 1–18 ACTH, Brit. Med. J., 3: 742.PubMedCrossRefGoogle Scholar
  12. London, D., Butt, W., and Marshall, J., 1973, Intranasal LH-releasing harmone, Lancet, i:1258.Google Scholar
  13. Potashnik, G., Ben-Adereth, N., Lunenfeld, B., and Rote, C., 1977, Nasal application of synthetic gonadotropin-releasing hormone in men, Fertil. Steril., 28: 650.PubMedGoogle Scholar
  14. Smith, R., 1952, Nasal administration of ACTH: observation of effectiveness measured by blood eosinopenic response, Endocrine Soc. Abst., 12:958.Google Scholar
  15. Ziegler, R., Holz, G., Steribl, W., and Raue, F., 1978, Nasal application of calcitonin in Paget’s disease of bone, Acta Endroc. Suppl., 215: 54.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Musetta Hanson
    • 1
  • G. Gazdick
    • 1
  • J. Cahill
    • 1
  • M. Augustine
    • 1
  1. 1.Pharmacy Research and DevelopmentRorer Group, Inc.TuckahoeUSA

Personalised recommendations