Microspheres as a Potential Controlled Release Nasal Drug Delivery System
The epithelial cells of the nasal mucosa are for the main part of the nasal cavity covered with numerous microvilli thereby increasing considerably the surface available for drug absorption. Furthermore, the subepithelial layer is highly vascularized with large and fenestrated capillaries specially designed for rapid passage of fluid through the vascular wall (Mygind, 1978). Unlike absorption from the gastrointestinal tract the venous blood draining from the nose passes directly into the systemic circulation and not into the portal circulation and thence to the liver. Thus, the nose is well suited for the absorption of drugs, especially those that are extensively metabolized in the gastrointestinal fluids and the gut wall or are subjected to an extensive first pass hepatic metabolism. The various regulatory peptides and proteins are good examples.
KeywordsNasal Cavity Nasal Mucosa Nasal Spray Polyacrylic Acid Penetration Enhancer
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