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The Oral Bioavailability of Peptides and Related Drugs

  • M. J. Humphrey
Part of the NATO ASI Series book series (NSSA, volume 125)

Abstract

The discovery of diverse neuro- and hormonal peptides, as well as other biologically-active peptides, has prompted investigations into their therapeutic applications and to the design of peptide drugs. However a contributing factor to the therapeutic success of a drug is the availability of an oral formulation. For peptides and proteins, oral absorption and bioavailability is generally low (as shown in Table 2) relative to that expected of non-peptide drugs (for review see Humphrey & Ringrose, 1986). The purpose of this review is to describe the various barriers to, and mechanisms of absorption of peptide drugs, as well as, to discuss the relationship between physio-chemical properties and absorption (see Table 1).

Keywords

Mucosal Barrier Peptide Drug Unstirred Water Layer Enalapril Maleate Mono Ethyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • M. J. Humphrey
    • 1
  1. 1.Department of Drug MetabolismPfizer Central ResearchSandwich, KentUK

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