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Advanced Delivery Systems for Peptides and Proteins — Pharmaceutical Considerations

  • S. S. Davis
Part of the NATO ASI Series book series (NSSA, volume 125)

Abstract

Presently, a wide variety of routes of administration and delivery systems exists for drug substances, but by far the most popular approach is oral delivery where the drug is intended to be absorbed from the gastrointestinal tract. Injectable systems (that include implants), suppositories and transdermal devices, have a more limited place in current therapy. Some of these administration systems can be employed directly for the delivery of peptides and proteins, however, others cannot be used in their present form and will require extensive modification. In particular, the delivery of peptides and proteins via the gastrointestinal tract will be especially difficult because of the inherent instability of such materials and the poor permeability of the intestinal mucosa to high molecular weight substances. Indeed it can be claimed that the process of evolution, over many thousands of years, has resulted in the gastrointestinal tract being impermeable to large molecular weight molecules in the adult mammal and that serious immunological consequences could arise if such materials happened to be taken up intact. This point will be discussed further below. In future the less well known routes of administration, namely nasal, vaginal and buccal, could play a more important role in the delivery of peptides and proteins because of their superior permeability characteristics or the fact that the dosage form can be retained at the site of administration for a prolonged period of time to maximise absorption.

Keywords

Signal Recognition Particle Biological Response Modifier Absorption Enhancer Muramyl Dipeptide Nasal Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • S. S. Davis
    • 1
  1. 1.Department of PharmacyUniversity of NottinghamNottinghamUK

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