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Metalloporphyrin Models for Cytochrome P-450

  • Chapter
Cytochrome P-450

Abstract

The elucidation of the molecular mechanisms of biological oxygen activation has been the focus of sustained attention for over a decade.1 In this time, cytochrome P-450 has become a Rosetta stone among the hemecontaining monooxygenases.2,3 The wide variety of oxygenations mediated by P-450 and the significance of these processes in steroid metabolism, drug detoxification, and the carcinogenic activation of polycyclic aromatic hydrocarbons have stimulated an effort to understand these processes. The selective hydroxylation of unactivated alkanes, in particular, lacks a classical paradigm in organic chemistry. Accordingly, there has been an effort to develop synthetic models of P-450 which might be used for the oxyfunctionalization of hydrocarbons. An understanding of the mechanism of these simple cases has begun to provide a conceptual base for the understanding of the enzymatic pathway.

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  1. Department of Chemistry, The University of Michigan, Ann Arbor, Michigan, 48109, USA

    Thomas J. McMurry & John T. Groves

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  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, 94143, San Francisco, California, USA

    Paul R. Ortiz de Montellano

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McMurry, T.J., Groves, J.T. (1986). Metalloporphyrin Models for Cytochrome P-450. In: de Montellano, P.R.O. (eds) Cytochrome P-450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9939-2_1

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