An Experimentalist’s View of Control Analysis

  • Daniel E. Atkinson
Part of the NATO ASI Series book series (NSSA, volume 190)


In Responding to the invitation to comment on some aspects of the symposium, I will attempt no evaluation of the internal logic or mathematical merits of the various mathematical treatments that have been discussed. Those and other characteristics of these treatments have been discussed by other participants. Rather, I will focus my comments mainly on two questions that Dr. Cornish-Bowden asked me to consider, and which he posed in his introductory presentation (see Chapter 1): (a) what characteristics should a theory have if it is to be useful to experimentalists and (b) are the main treatments that have been discussed here — those of Kacser and Burns (see especially Chapters 3, 17, 20 and 25), Heinrich and Rapoport (Chapter 28), and Savageau (Chapters 4 and 5) — valuable to experimental metabolic biochemists?


Metabolic Regulation Mathematical Treatment Control Coefficient Heat Leak Qualitative Question 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Crabtree, B. & Newsholme, E. A. (1987) Trends Biochem. Sci. 12, 4–12CrossRefGoogle Scholar
  2. Heinrich, R.& Rapoport, T. A. (1974) Eur. J. Biochem. 42, 107–120CrossRefGoogle Scholar
  3. Kacser, H. & Burns, J. A. (1973) Symp. Soc. Exp. Biol. 27, 65–104PubMedGoogle Scholar
  4. Sauro, H. M. & Fell, D. A. (1987) Biochem. Soc. Trans. 15, 234–235Google Scholar
  5. Umbarger, H. E. (1956) Science 123, 848PubMedCrossRefGoogle Scholar
  6. Yates, R. A. & Pardee, A. B. (1956) J. Biol. Chem. 221, 757–770PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Daniel E. Atkinson
    • 1
  1. 1.Department of Chemistry and BiochemistryUniversity of CaliforniaLos AngelesUSA

Personalised recommendations