Application of Metabolic Control Analysis to Photosynthesis: the Problem of Getting Data for an Impressive Algorithm
The Mathematics of metabolic control theory is simple, not complicated as could be inferred from the literature. The differential equations describing the time course of metabolite concentrations, and qualitative knowledge of reaction rates allow formulation of two matrices. Control coefficients can then be determined from enzyme elasticities by standard matrix algebra. This procedure is used to calculate symbolically control coefficients of photosynthetic reactions. Also peculiarities of photosynthesis (light-driven reactions, high enzyme concentrations in combination with constraints) that require extension to control theory can be treated by this approach.
KeywordsMetabolite Concentration Elasticity Matrix Bisphosphate Carboxylase Triose Phosphate Control Coefficient
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