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Metabolic Control by the Cyclic Cascade Mechanism: a Study of E. coli Glutamine Synthetase

  • P. Boon Chock
  • Sue Goo Rhee
  • Earl R. Stadtman
Chapter
Part of the NATO ASI Series book series (NSSA, volume 190)

Abstract

The cyclic cascade model was developed through detailed studies on the regulation of Escherichia coli glutamine synthetase. This enzyme catalyses the biosynthesis of glutamine and since the amide nitrogen atom of glutamine is a preferred nitrogen source for the biosynthesis of virtually all amino acids, purine and pyrimidine nucleotides, NAD and glucosamine-6-phosphate, it is rigorously regulated in bacteria which synthesize their own amino acids. [For reviews, see Stadtman & Ginsburg (1974), Stadtman & Chock (1978), Chock et al., (1980), Rhee et al., (1985).]

Keywords

Glutamine Synthetase Converter Enzyme Signal Amplification Rate Amplification Allosteric Effector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson, W. W. and Stadtman, E. R. (1970) Biochem. Biophys. Res. Commun. 41, 704–709PubMedCrossRefGoogle Scholar
  2. Brown, M. S., Segal, A. and Stadtman, E. R. (1971) Proc. Natl. Acad. Sci. USA 68, 2949–2953PubMedCrossRefGoogle Scholar
  3. Caban, C. E. and Ginsburg, A. (1976) Biochemistry 15, 1569–1580PubMedCrossRefGoogle Scholar
  4. Cárdenas, M. L. and Cornish-Bowden, A. (1989) Biochem. J. 257, 339–345PubMedGoogle Scholar
  5. Chock, P. B. and Stadtman, E. R. (1977) Proc. Nail. Acad. Sci. USA 74, 2766–2770CrossRefGoogle Scholar
  6. Chock, P. B. and Stadtman, E. R. (1979) XXX, in Modulation of Protein Function ( Atkinson, D. E. and Fox, C. F., eds.), Academic Press, New York, pp. 185–202Google Scholar
  7. Chock, P. B., Rhee, S. G. and Stadtman, E. R. (1980) Annu. Rev. Biochem. 49, 813–843PubMedCrossRefGoogle Scholar
  8. Danforth, W. H., Heimreich, E. and Cori, C. F. (1962) Proc. Natl. Acad. Sci. USA 48, 1191–1199PubMedCrossRefGoogle Scholar
  9. El-Maghrabi, M. R., Claus, T. H., Pilkis, J., Fox, E. and Pilkis, S. J. (1982) J. Biol. Chem. 257, 7603-7607 Google Scholar
  10. Garcia, E. and Rhee, S. G. (1983) J. Biol. Chem. 258, 2246–2253PubMedGoogle Scholar
  11. Goldbeter, A. and Koshland, D. E. Jr. (1981) Proc. Natl. Acad. Sci. USA 78, 6840–6844PubMedCrossRefGoogle Scholar
  12. Goldbeter, A. and Koshland, D. E. Jr. (1987) J. Biol. Chem. 262, 4460–4471PubMedGoogle Scholar
  13. Hirschman, J., Wong, P. K., Sei, K., Keener, J. and Kustu, S. (1985) Proc. Natl. Acad. Sci. USA 82, 7525–7529PubMedCrossRefGoogle Scholar
  14. Jurgensen, S. R., Chock, P. B., Taylor, S., Vandenheede, J. R. and Merlevede, W. (1985) Proc. Natl. Acad. Sci. USA 82, 7565–7569PubMedCrossRefGoogle Scholar
  15. Keener, J. and Kustu, S. (1988) Proc. Natl. Acad. Sci. USA 85, 4976–4980PubMedCrossRefGoogle Scholar
  16. Keener, J., Wong, P., Popham, D., Wallis, J. and Kustu, S. (1987) XXX, in RNA Polymerase and the Regulation of Transcription ( Reznikoff, W. S., Burgess, R. R., Dahlberg, J. E., Gross, C. A., Record, M. T., Jr. and Wickens, M. P., eds.), Elsevier Science Publishers, New York, pp. 159–175Google Scholar
  17. Kustu, S., Sei, K. and Keener, J. (1986) XXX, in Regulation of Gene Expression ( Booth, I. R. and Higgins, C. F., eds.), Cambridge University Press, Cambridge, Massachusetts, pp. 139–154Google Scholar
  18. LaPorte, D. C. and Koshland, D. E., Jr. (1982) Nature 300, 458–460PubMedCrossRefGoogle Scholar
  19. Lipmann, F. (1981) Curr. Topics Cell. Regn. 18, 301–311Google Scholar
  20. Magasanik, B. (1982) Annu. Rev. Gen. 16, 135–168CrossRefGoogle Scholar
  21. Mantel, M. and Holzer, H. (1970) Proc. Natl. Acad. Sci. USA 65, 660–667PubMedCrossRefGoogle Scholar
  22. Meinke, M. H., Bishop, J. S. and Edstrom, R. D. (1986) Proc. Natl. Acad. Sci. USA 83, 2865–2868PubMedCrossRefGoogle Scholar
  23. Mura, U., Chock, P. B. and Stadtman, E. R. (1981) J. Biol. Chem. 256, 13022–13029PubMedGoogle Scholar
  24. Ninfa, A. J., Reitzer, L. J. and Magasanik, B. (1987) Cell 50, 1039–1046PubMedCrossRefGoogle Scholar
  25. Pettit, F. H., Pelley, J. W. and Reed, L. J. (1975) Biochem. Biophys. Res. Commun. 65, 575–582PubMedCrossRefGoogle Scholar
  26. Rhee, S. G., Park, R., Chock, P. B. and Stadtman, E. R. (1978) Proc. Natl. Acad. Sci. USA 75, 3138–3142PubMedCrossRefGoogle Scholar
  27. Rhee, S. G., Bang, W. G., Koo, J. H., Min, K. H. and Park, S. C. (1988) XXX, in Enzyme Dynamics and Regulation ( Chock, P. B., Huang, C. Y., Tsou, C. L. and Wang, J. H., eds.), Springer-Verlag, New York, pp. 136–145Google Scholar
  28. Rhee, S. G., Chock, P. B. and Stadtman, E. R. (1989) Adv. Enzymol. 62, 37–92Google Scholar
  29. Segal, A., Brown, M. A. and Stadtman, E. R. (1974) Arch. Biochem. Biophys. 161, 319–327CrossRefGoogle Scholar
  30. Senior, P. (1975) J. Bacteriol. 132, 407–418Google Scholar
  31. Shacter, E., Chock, P. B. and Stadtman, E. R. (1984) J. Biol. Chem. 259, 12252–12259PubMedGoogle Scholar
  32. Stadtman, E. R., Shapiro, B. M., Ginsburg, A., Kingdon, H. S. and Denton, M. D. (1968) Brookhaven Symp. Biol. 21, 378–396PubMedGoogle Scholar
  33. Stadtman, E. R. and Ginsburg, A. (1974) The Enzymes (3rd edn.) 10, 755–807Google Scholar
  34. Stadtman, E. R. and Chock, P. B. (1977) Proc. Natl. Acad. Sci. USA 74, 2761–2766PubMedCrossRefGoogle Scholar
  35. Stadtman, E. R. and Chock, P. B. (1978) Curr. Topics Cell. Reg. 13, 53–95Google Scholar
  36. Stadtman, E. R. and Chock, P. B. (1979) XXX, in The Neurosciences: Fourth Study Program ( Schmitt, F. O., ed.), MIT Press, Cambridge, Massachusetts, pp. 801–817Google Scholar
  37. Stadtman, E. R., Chock, P. B. and Rhee, S. G. (1979) XXX, in Modulation of Protein Function ( Atkinson, D. E. and Fox, C. F., eds.), Academic Press, New York, pp. 203–217Google Scholar
  38. van Schaftingen, E., Davies, D. R. and Hers, H. G. (1982) Eur. J. Biochem. 124, 143–149PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • P. Boon Chock
    • 1
  • Sue Goo Rhee
    • 1
  • Earl R. Stadtman
    • 1
  1. 1.Laboratory of Biochemistry, National Heart, Lung and Blood InstituteNational Institutes of HealthBethesdaUSA

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