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Effects of Enflurane on the Ventilatory Response to Increased Carbon Dioxide and Metabolic Rate in Dogs

  • D. S. Ward
  • R. Ginsburg
  • I. H. Abdul-Rasool
  • K. Aqleh

Abstract

Inhaled anesthetic agents cause a dose related ventilatory depression as evidenced by an increase in arterial PCO2 (PaCO2) and blunting of the ventilatory response to hypercapnia and hypoxia (Hirschman et al., 1977). Ventilation is also closely coupled to metabolic rate, resulting in regulation of PaCO2 in spite of changes in metabolic rate (Wasserman et al., 1986). This study investigates the effects of inhalational anesthetics on this coupling.

Keywords

Ventilatory Response Breathing Frequency Hypoxic Ventilatory Response External Electrical Stimulation Exercise Hyperpnea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hirschman, C.A., McCullough, R.E., Cohen, J.P., and Weil, J.V., 1977, Depression of hypoxic ventilatory response by halothane, enflurane and isoflurane in dogs, Br. Jr. Anaesth. 49: 957.CrossRefGoogle Scholar
  2. Wasserman, K., Whipp, B.J., and Cassaburi, R., 1986, Respiratory control during exercise. in: “Handbook of Physiology, Section 3, The Respiratory System, Vol. II, Control of Breathing, Part 2”,N.S. Cherniack and J.G.Widdicombe, eds., American Physiological Society, Washington, D.C.Google Scholar
  3. Chonan, T., Kikuchi, Y., Hida, W., Shindoh, C., Inoue, H., Sasaki, H., and Takishima, T., 1984, Response to hypercapnia and exercise hyperpnea in graded anesthesia, J. Appl. Physiol. 57: 1796.PubMedGoogle Scholar
  4. Hida, W., Shindoh, C., Kikuchi, Y., Chonan, T., Inoue, H., Sasaki, H., and Takishima, T., 1986, Ventilatory response to phasic contraction and passive movement in graded anesthesia, J. Appl. Physiol. 61: 91.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • D. S. Ward
    • 1
  • R. Ginsburg
    • 1
  • I. H. Abdul-Rasool
    • 1
  • K. Aqleh
    • 1
  1. 1.Department of AnesthesiologyUCLA Medical SchoolLos AngelesUSA

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