Effects of Enflurane on the Ventilatory Response to Increased Carbon Dioxide and Metabolic Rate in Dogs
Inhaled anesthetic agents cause a dose related ventilatory depression as evidenced by an increase in arterial PCO2 (PaCO2) and blunting of the ventilatory response to hypercapnia and hypoxia (Hirschman et al., 1977). Ventilation is also closely coupled to metabolic rate, resulting in regulation of PaCO2 in spite of changes in metabolic rate (Wasserman et al., 1986). This study investigates the effects of inhalational anesthetics on this coupling.
KeywordsVentilatory Response Breathing Frequency Hypoxic Ventilatory Response External Electrical Stimulation Exercise Hyperpnea
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