Influence of the Neurohormones: Human Corticotropin Releasing Factor (hCRF), Thyrotropin Releasing Hormone (TRH), Adrenocorticotropic Hormone (ACTH) on Ventilation in Humans

  • M. Nink
  • I. Huber
  • U. Krauze
  • H. Lehnert

Abstract

While exploring the biological effects of i.v. — administered hCRF in volunteers, we observed a marked ventilatory stimulation which was obviously provoked by hCRF (Oppermann et al., 1985). In a controlled study we demonstrated a highly significant ventilatory analeptic effect in 13 healthy male and female subjects. This effect was dose-dependent, minute volume and tidal volume rose markedly. Breathing frequency was not found to be altered (Nink et al., 1988 in press).

Keywords

Placebo Depression Respiration Dexamethasone Epinephrine 

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • M. Nink
    • 1
  • I. Huber
    • 2
  • U. Krauze
    • 2
  • H. Lehnert
    • 2
  1. 1.Dept. of PneumologyUniversity HospitalGermany
  2. 2.Dept. of Endocrinology MainzUniversity HospitalGermany

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