Control of Breathing by Neuropeptides
Respiratory rhythm is partly generated by the periodic actions of classical neurotransmitters which act at the synapse level between different types of respiratory neurons. Periodic glutamate-like excitations (Denavit-Saubié et al., 1978) have been described as well as GABA- and glycine-like inhibitions (Champagnat et al., 1982). A new type of neuroactive substance, neuropeptides, are present in the respiratory networks and are involved in the control of the respiratory rhythm. We have been interested in those which are released in the nucleus tractus solitarii (NTS): cholecystokinin, enkephalins, substance P, neurotensin (Morin-Surun et al., 1983, 1984a,b,c, 1986; Hurlé et al., 1985a).
KeywordsOpioid Peptide Nucleus Tractus Solitarii Respiratory Rhythm Respiratory Neuron Neuroactive Substance
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