The Effect of Chronic Pulmonary Denervation on the Pattern of Breathing during Sleep in Man
In most mammals vagal afferents from the lungs play an important role in the control of breathing — without them breathing becomes significantly slower and deeper (eg. Hering and Breuer, 1868) and more variable (Kelsen et al., 1982). However, in healthy man at rest most evidence suggests that the effect of vagal afferents upon the pattern of breathing is negligible (Guz et al., 1964; Cross et al., 1976; Winning et al., 1985). These studies have used different techniques to achieve acute reversible vagal block and they have not been completely selective for the pulmonary innervation.
KeywordsSleep Stage Vagal Afferents Respiratory Inductance Plethysmography Undergo Heart Transplantation Multiple Linear Regression Technique
Unable to display preview. Download preview PDF.
- Cross, B.A., Guz, A., Jain, S.K., Archer, S., Stevens, J., and Reynolds F., 1976, The effect of anaesthesia of the airway in dog and man: a study of respiratory reflexes, sensations and lung mechanics, Clin. Sci. Mol. Biol., 50: 439.Google Scholar
- Hering, E., and Breuer, J., 1970, Self-steering of respiration through the nervus vagus, (First published 1868), in: “Breathing; Hering-Breuer Centenary Symposium”, Porter R.J., and Churchill A., eds., London.Google Scholar
- Shea, S.A., Walter, J., Murphy, K., and Guz, A., 1987, Evidence for the individuality of breathing patterns in resting healthy man, Resp. Physiol., 68: 331.Google Scholar
- Winning, A.J., Hamilton, R.D., Shea, S.A., Knott, C., and Guz, A., 1985, The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man, Clin. Sci., 68:215.Google Scholar