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The Effect of Chronic Pulmonary Denervation on the Pattern of Breathing during Sleep in Man

  • S. A. Shea
  • R. L. Horner
  • E. McKenzie
  • N. R. Banner
  • M. H. Yacoub
  • A. Guz

Abstract

In most mammals vagal afferents from the lungs play an important role in the control of breathing — without them breathing becomes significantly slower and deeper (eg. Hering and Breuer, 1868) and more variable (Kelsen et al., 1982). However, in healthy man at rest most evidence suggests that the effect of vagal afferents upon the pattern of breathing is negligible (Guz et al., 1964; Cross et al., 1976; Winning et al., 1985). These studies have used different techniques to achieve acute reversible vagal block and they have not been completely selective for the pulmonary innervation.

Keywords

Sleep Stage Vagal Afferents Respiratory Inductance Plethysmography Undergo Heart Transplantation Multiple Linear Regression Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cross, B.A., Guz, A., Jain, S.K., Archer, S., Stevens, J., and Reynolds F., 1976, The effect of anaesthesia of the airway in dog and man: a study of respiratory reflexes, sensations and lung mechanics, Clin. Sci. Mol. Biol., 50: 439.Google Scholar
  2. Guz, A., Noble, M.I.M, Trenchard, D., Cochrane, H.L., and Makey, A.R., 1964, Studies on the vagus nerves in man: their role in respiratory and circulatory control, Clin. Sci., 27: 293.PubMedGoogle Scholar
  3. Hering, E., and Breuer, J., 1970, Self-steering of respiration through the nervus vagus, (First published 1868), in: “Breathing; Hering-Breuer Centenary Symposium”, Porter R.J., and Churchill A., eds., London.Google Scholar
  4. Kelsen, S.G., Shustack, A., and Hough, W., 1982, The effect of vagal blockade on the variability of ventilation in the awake dog, Resp. Physiol., 49: 339.CrossRefGoogle Scholar
  5. Shea, S.A., Walter, J., Murphy, K., and Guz, A., 1987, Evidence for the individuality of breathing patterns in resting healthy man, Resp. Physiol., 68: 331.Google Scholar
  6. Winning, A.J., Hamilton, R.D., Shea, S.A., Knott, C., and Guz, A., 1985, The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man, Clin. Sci., 68:215.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • S. A. Shea
    • 1
    • 2
  • R. L. Horner
    • 1
    • 2
  • E. McKenzie
    • 1
    • 2
  • N. R. Banner
    • 1
    • 2
  • M. H. Yacoub
    • 1
    • 2
  • A. Guz
    • 1
    • 2
  1. 1.Department of MedicineCharing Cross and Westminster Medical SchoolLondon
  2. 2.Cardiothoracic UnitHarefield HospitalMiddlesexUK

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