The Role of Ventral Group Neurons in the Respiratory Depression during Carbachol-Induced Rem Sleep Atonia

  • H. Kimura
  • L. Kubin
  • H. Tojima
  • A. I. Pack
  • R. O. Davies


Sleep-related decreases in the tone of upper airway and respiratory pump muscles occur most frequently in association with the rapid eye movement (REM) phase of sleep and its characteristic postural muscle atonia12. These decreases in muscle tone may lead to upper airway obstruction and/or reduced tidal volume in patients with sleep apnea syndrome.


Phrenic Nerve Cholinergic Stimulation Pontine Tegmentum Peak Firing Phrenic Nerve Activity 


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • H. Kimura
    • 1
  • L. Kubin
    • 1
  • H. Tojima
    • 1
  • A. I. Pack
    • 2
  • R. O. Davies
    • 1
  1. 1.School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Center for Sleep and Respiratory NeurobiologyUniversity of PennsylvaniaPhiladelphiaUSA

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