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Cranial Nerve and Phrenic Respiratory Rhythmicity during Changes in Chemical Stimuli in the Anesthetized Rat

  • Yasuichiro Fukuda

Abstract

Central respiratory rhythmicity and/or timing has been determined by the trajectory of phrenic (Phr) nerve discharges. Cranial nerves innervating the upper airway muscles also display respiratory modulated activity synchronized with Phr activity. These cranial nerve motoneurons as well as spinal Phr motoneurons (or Phr driving medullary pre-motor neurons) are driven by a common rhythm generating mechanism. There are, however, significant differences in the discharge pattern and responses to chemical stimuli between Phr and cranial nerve respiratory activity1. The onset of inspiratory activity of the cranial nerves is much earlier than that of Phr nerve2, 3, 4. Changes in chemical stimuli (Pao2, Paco2) initiate differential effects on I activity among various respiratory nerves, including Phr and cranial nerves3, 5, 6, 7. On the other hand, cranial nerve respiratory activities are sensitive to anesthesia and/or sleep stage, and hence have not been considered as major output signals for observation of central respiratory rhythmicity8, 9, 10. In the present experiment we found that the glossopharyngeal (IX) nerve I activity showed much smaller suppression during hypocapnia or hypoxia than the Phr I discharge did. Furthermore a small ramp-like rhythmic IX activity even without Phr burst was seen during hypocapnic or hypoxic respiratory suppression.

Keywords

Cranial Nerve Recurrent Laryngeal Nerve Phrenic Nerve Chemical Stimulus Carotid Sinus Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    C. Von Euler, On the central pattern generator for the basic breathing rhythmicity. J. Appl. Physiol. 55:1647(1983).Google Scholar
  2. 2.
    M.I. Cohen, Phrenic and recurrent laryngeal discharge patterns and the Hering-Breuer reflex. Amer.J.Physiol. 228:1489(1975).PubMedGoogle Scholar
  3. 3.
    Y. Fukuda, and Y. Honda, Effects of hypocapnia on respiratory timing and inspiratory activities of the superior laryngeal, hypoglossal, and phrenic nerves in the vagotomized rat. Jpn. J. Physiol. 33:733(1983).PubMedCrossRefGoogle Scholar
  4. 4.
    Y. Fukuda, and Y. Honda, Modification by chemical stimuli of temporal difference in the onset of inspiratory activity between vagal (superior laryngeal) or hypoglossal and phrenic nerves of the rat. Jpn. J. Physiol. 38:309 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    S. D. Iscoe, Central control of the upper airway, in: “Respiratory function of the upper airway”, O. P. Mathew and G. Sant’Ambriogio, eds., Marcel Dekker, New York-Basel (1988).Google Scholar
  6. 6.
    D. Weiner, J. Mitra, J. Salamone, and N.S. Cherniack, Effect of chemical stimuli on nerve supplying upper airway muscles. J. Appl.Physiol. 52:530(1982).PubMedGoogle Scholar
  7. 7.
    D. Zhou, Q. Huang, W.M. St. John, and D. Bartlett, Jr, Respiratory activities of intralaryngeal branches of the recurrent laryngeal nerve, J. Appl. Physiol. 67:1117(1989)Google Scholar
  8. 8.
    M.I. Cohen, Neurogenesis of respiratory rhythm in the mammal. Physiol. Rev. 59:1105 (1979).PubMedGoogle Scholar
  9. 9.
    J.L. Feldman, Neurophysiology of breathing in mammals, in: “Handbook of physiology, sect. 1, The nervous system, Vol.1”, V. B. Mountcastle, F.E. Bloom, and S.R. Geiger, eds., Amer. Physiol. Soc., Bethesda, (1986).Google Scholar
  10. 10.
    Y. Murakami, and J.I. Kirchner, Respiratory activity of the external laryngeal muscles: an electromyographic study in the cat, in: “Ventilatory and phonatory control”, D. Wyke, ed., Oxford Univ. Press, London (1974).Google Scholar
  11. 11.
    Y. Fukuda, A. Sato, and A. Trzebski, Carotid chemoreceptor discharge responses to hypoxia and hypercapnia in normotensive and spontaneously hypertensive rats. J. Auton. Nerv. Syst. 19:1(1987).PubMedCrossRefGoogle Scholar
  12. 12.
    Y. Fukuda, W.R. See, and Y. Honda, Effect of halothane anesthesia on end-tidal Pco2 and pattern of respiration in the rat. Pflügers Arch. 392:244(1982).PubMedCrossRefGoogle Scholar
  13. 13.
    H. Tojima, T. Kuriyama, and Y. Fukuda, Arterial to end-tidal Pco2 differnce varies with different ventilatory conditions during steady state hypercapnia in the rat, Jpn. J. Physiol. 38:445(1988).PubMedCrossRefGoogle Scholar
  14. 14.
    Y. Fukuda, Hypoxic inhibition of respiratory neural regulation in anesthetized rats, Jpn.J.Physiol. 41:893(1991).PubMedCrossRefGoogle Scholar
  15. 15.
    Y. Fukuda, Differences in glossopharyngeal and phrenic inspiratory activities of rats during hypocapnia and hypoxia, Neurosci Lett. (1992)In press.Google Scholar
  16. 16.
    D. Bieger, and D.A. Hopkins, Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: The nucleus ambiguus, J. Comp. Neurol. 262:546(1987).PubMedCrossRefGoogle Scholar
  17. 17.
    H. Ellenberger, and J.L. Feldman, Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats, J. Comp. Physiol, 269:47(1988).Google Scholar
  18. 18.
    N.S. Cherniack, N.H. Edelman, and S. Lahiri, Hypoxia and hypercapnia as respiratory stimulants and depressants, Respir. Physiol. 11:113(1970/71).PubMedCrossRefGoogle Scholar
  19. 19.
    R. Maruyama, A. Yoshida, and Y. Fukuda, Differential sensitivity to hypoxic inhibition of respiratory processes in the anesthetized rat, Jpn. J. Physiol. 39:857(1989).PubMedCrossRefGoogle Scholar
  20. 20.
    J.A. Neubauer, J.E. Melton, and N.H. Edelman, Modulation of respiration during hypoxia, J. Appl. Physiol. 68:441(1990).PubMedGoogle Scholar
  21. 21.
    W.M.St. John, D. Bartlett, Jr, K.V. Knuth, and J.C. Hwang, Brain stem genesis of automatic ventilatory patterns independent of spinal mechanisms. J.Appl. Physiol. 51:204(1981).Google Scholar
  22. 22.
    J.C. Smith, J.J. Greer, G. Liu, and J.L. Feldman, Neural mechanisms generating respiratory pattern in mammalian brainstem-spinal cord in vitro. I Spatio-temporal patterns of motor and medullary neuron activity. J. Neurophysiol. 64:1149(1990).Google Scholar
  23. 23.
    S.W. Schwarzacher, Z. Wilhelm, K. Anders, and D.W. Richter, The medullary respiratory network in the rat. J. Physiol.(Lond.) 435:631(1991).Google Scholar
  24. 24.
    H. Onimaru, A. Arata, and I. Homma, Primary respiratory rhythm generator in the medulla of brainstem-spinal cord preparation from newborn rat. Brain Res. 445:314(1988).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Yasuichiro Fukuda
    • 1
  1. 1.Department of Physiology II, School of MedicineChiba UniversityChibaJapan

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