Abstract
Serotonin or 5-hydroxytryptamine (5-HT) is known to be widely distributed in the brain (Dahlström and Fuxe, 1964) and has been implicated in various physiological and behavioral functions, such as REM sleep (Jouvet, 1969), neuropsychiatric disorder (Peroutka and Snyder, 1980), thermoregulation (Gudelsky et al., 1986), cardiovascular control (Lovick, 1989), and so on. The present study is conducted to evaluate a role of serotonin in the control of upper airway. Using a micropressure ejection method (Kogo and Arita, 1990), we have tested responsiveness of the medullary inspiratory neurons to direct applications of serotonin, in comparison with applications of glutamate and noradrenaline. Furthermore, we have examined modes of 5-HT terminals on the medullary motoneurons projecting to the dilator muscles of the larynx, by means of combined techniques of retrograde labelling with unconjugated choleratoxin subunh-B and immunohistochemistry with an antiserum against serotonin. The present physiological and morphological results are discussed in relation to a possible role of the serotoninergic system in airway obstruction during sleep.
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References
Arita, H., and Ochiishi, M., 1991, Oppsing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns, J. Neurophysiol. 66:285.
Cohen, M.I., 1979, Neurogenesis of respiratory rhythm in the mammal. Physiol. Rev. 59:1105.
Conway, W.A., Zorick, F., Piccione, P., and Roth, T., 1982, Protriptyline in the treatment of sleep apnoea. Thorax 37:49.
Dahlström, A., and Fuxe, K., 1964, Evidence for the existence of monoamine-containing neurons in the central nervous system, Acta Physiol. Scand. 62:1.
Davies, PJ., and Nail, B.S., 1984, On the location and size of laryngeal motoneurons in the cat and rabbit. J. Comp. Neurol. 230:13.
Gudelsky, G.A., Koenig, J.I., and Meltzer, H.Y., 1986, Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Neuropharmacolgy 25:1307.
Jouvet, M., 1969, Biogenic amines and the states of sleep. Science 163:32.
Kogo, N., and Arita, H., 1990, In vivo study on medullary H+-sensitive neurons. J. Appl. Physiol. 69:1408.
Lovick, T.A., 1989, Cardiovascular responses to 5-HT in the ventrolateral medulla of the rat. J. Auton. Nerv. Syst. 28:35.
Moor, R.Y., 1981, The anatomy of central serotonin neuron systems in the rat brain, in:“Serotonin Neurotransmission and Behavior,” B.L. Jacobs, A. Gelperin, ed., MIT Press, Cambridge.
Peroutka, S.J., and Snyder, S.H., 1980, Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210:88.
Remmers, D.W., and Bartlett, DJr., 1977, Reflex control of expiratory flow and duration., J. Appl. Physiol. 42:80.
Richter, D.W., 1982, Generation and maintenance of the respiratory rhythm. J. Exp. Biol. 100:93.
Rudomin, P., 1966, The electrical activity of the cricothyroid muscles of the cat Arch Int. Physiol. Biochem. 74:135.
Sherrey, J.H., and Megirian, D., 1980, Respiratory EMG activity of the posterior cricoarytenoid, cricothyroid and diaphragm muscles during sleep. Respir. Physiol. 39:355.
Trulson, M.E., and Jacobs, B.L., 1979, Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal. Brain Res. 106:105.
Woodson, G.E., Sant’Ambrogio, F.B., Mathew, O.P., and Sant’Ambrogio, G., 1989, Effects of cricothyroid muscle contraction on laryngeal resistance and glottic area. Ann. Otol. Rhinol. Laryngol. 98:119.
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© 1992 Springer Science+Business Media New York
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Arita, H., Sakamoto, M. (1992). Role of Serotonin in Airway Patency: Physiological and Morphological Evidence for Serotoninergic Inputs to Laryngeal Inspiratory Motoneurons. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_37
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DOI: https://doi.org/10.1007/978-1-4757-9847-0_37
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