Raphe Magnus-Induced Inhibition of Medullary and Spinal Respiratory Activities in the Cat
Electrical stimulation of the medullary raphe complex results in significant changes in the discharge patterns of respiratory neurons and phrenic motoneurons. Recent studies by us1, 2 and others3, 4 have demonstrated that stimulation in the nucleus raphe magnus (NRM) produced marked inhibitory effects on respiratory activities in cats and other animals. Previous studies5–7 have also provided evidence for the involvement of several putative transmitter substances such as serotonin (5-hydroxytryptamine) and other transmitters in raphe induced responses.
KeywordsElectrical Stimulation Phrenic Nerve Chemical Stimulation Unit Discharge Nucleus Raphe Magnus
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- 1.M. Aoki, Y. Fujito, Y. Kurosawa, H. Kawasaki, and I. Kosaka, Descending inputs to the upper cervical inspiratory neurons from the medullary respiratory neurons and the raphe nuclei in the cat, in: “Respiratory Muscles and Their Neuromotor Control,” G. C. Sieck, S. C. Gandevia, W. E. Cameron, eds., A. R. Liss, New York, pp 75–82 (1987).Google Scholar
- 5.P.M. Lalley, Serotonergic and non-serotonergic responses of phrenic motoneurones to raphe stimulation in the cat, J. Physiol. 308:373–385 (1986).Google Scholar
- 9.A. Haji, R. Takeda and J.E. Remmers, GABA-mediated inhibitory mechanisms in control of respiratory rhythm, in: “Control of Breathing and Dyspnea,” T. Takishima and N.S. Cherniack, eds., Pergamon, Oxford-New York, pp 61–63 (1991).Google Scholar
- 18.M. Aoki, Y. Nakazono and A. Mizuguchi, Inhibitory effects induced by electrical and chemical stimulation of the nucleus raphe magnus on respiratory activities, Jap. J. Physiol. 41: Suppl., S 234 (1991).Google Scholar
- 19.M. Aoki, Y. Nakazono and A. Mizuguchi, Respiratory inhibitom from nuclus naphe magnus and its reversal by a GABA antagonist, Abstr. 3rd IBRO World Congress of Neurosience, P123 (1991).Google Scholar
- 21.M. Aoki, Respiratory-related neuron activities in the cervical cord of the cat. in: Proceedings of the International Symposium. “Central Neural Production of Periodic Respiratory Movements”, J.R. Feldman, A.J. Berger, eds., Northwestern Univ., Chicago, pp 155–156 (1982).Google Scholar