Hypoxic Depression of Respiration
Hypoxia is one of the more common and serious stresses challenging homeostasis. Apart from its effects on specialized O2 sensing chemoreceptors, hypoxia has direct effects on all the tissues of the body. The tissues of the central nervous system (CNS) are probably the most vulnerable to the injurious actions of low levels of oxygen. Because of the importance of the CNS as an organizer of integrated responses, CNS reactions to subnormal oxygenation underlie the responses of the body as a whole to acute and chronic hypoxia. The response of the CNS to hypoxia is of obvious importance in unraveling the mechanisms that participate in altitude adaptation, diseases which produce global hypoxia (chronic lung disease of the adult and infant), and diseases which produce local cerebral hypoxia (cerebral ischemia and convulsive disorders).
KeywordsSympathetic Activity Phrenic Nerve Sympathetic Nerve Activity Carotid Body Sodium Cyanide
J.A. Neubauer, J.E. Melton and N.H. Edelman. Modulation of respiration during brain hypoxia. J. Appl. Physiol.
68:441–451 (1990).PubMedGoogle Scholar
H.W. Davenport, G. Brewer, A.H. Chambers and S. Goldschmidt. The respiratory response to anoxemia of unanesthetized dogs with chronically denervated aortic and carotid chemoreceptors and their causes. Am. J. Physiol.
148:406–417 (1947).PubMedGoogle Scholar
N.S. Cherniack, N.H. Edelman and S. Lahiri. Hypoxia and hypercapnia as respiratory stimulants and depressants. Respir. Physiol.
11:113–126 (1970).PubMedCrossRefGoogle Scholar
J.A. Neubauer, A. Simone and N.H. Edelman. Role of brain lactic acidosis in hypoxic depression of respiration. J. Appl. Physiol.
65:1324–31 (1988).PubMedGoogle Scholar
N.R. Prabhakar, J. Mitra, J.L. Overholt and N.S. Cherniack. Analysis of postinspiratory activity of phrenic motoneurons with chemical and vagal reflexes. J. Appl. Physiol.
61:1499–1509 (1986).PubMedGoogle Scholar
E. van Lunteren, R.J. Martin, M.A. Haxhiu and W.A. Carlo. Diaphragm, genioglossus and triangularis sterni responses to poikilocapnic hypoxia. J. Appl. Physiol.
L.M. Oyer, J.E. Melton, J.A. Neubauer and N.H. Edelman. Enhancement of expiratory triangularis sterni nerve (TSN) activity following severe hypoxia. FASEB J.
3:A1159 (1989).Google Scholar
W.A. Carlo, J.M. DiFiore and R.J. Martin. Increased upper airway muscle activity during hypoxemia-induced respiratory depression in preterm infants. Pediatr. Res.
25:373A (1989).CrossRefGoogle Scholar
D.A. Hutt, R.A. Parisi, T.V. Santiago and N.H. Edelman. Brain hypoxia preferentially stimulates genioglossal EMG response to CO2
. J. Appl. Physiol.
66:51–56 (1989).PubMedGoogle Scholar
P.G. Aitken and D.J. Braitman. The effects of cyanide on neural and synaptic function in hippocampal slices. Neurotoxicology
10:239–248 (1989).PubMedGoogle Scholar
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