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Role of Cl--HCO3- Exchanger and Anion Channel in the Cat Carotid Body Function

  • Rodrigo Iturriaga
  • Sukhamay Lahiri

Abstract

Carotid body (CB) chemosensory responses to respiratory and metabolic acidosis are well demonstrated both in vivo and in vitro 1. The responses are expected to originate from the chemoreceptor cells which usually should manifest parallel phenomena. The consensus model of the chemoreceptor unit is that the glomus cells are the presynaptic chemoreceptor cells and the sensory fibers are the postsynaptic elements which, we supposed, should reflect the events in the presynaptic glomus cells. However, Buckler et al.2 and Wilding et al.3 reported that the glomus cells possessed at least three ion-exchangers which regulated the intracellular pH (pHi). If the chemosensory responses are coupled to the pHj of the glomus cell and its pHi is well regulated then there will be a lack of correspondence between the glomus cell pHi and the sensory response to CO2-H+. Accordingly the role of the ion-exchangers would appear ambivalent.

Keywords

Carotid Body Glomus Cell Carotid Sinus Nerve Chemosensory Response Chemoreceptor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Rodrigo Iturriaga
    • 1
  • Sukhamay Lahiri
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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