Effects of Hypercapnia on Nasal Reflex Responses Elicited by Nasal Insufflation of Isoflurane in Lightly-Anesthetized Humans
Stimulation of nasal mucosa elicits nasal reflexes which are defensive in nature. In a previous study1 we showed that in anesthetized humans nasal irritation with high concentrations of commonly-used volatile anesthetics causes changes in respiratory pattern characterized by prolongation of expirtatory time. Although it has been reported m several studies2-5 that an increase in chemical ventilatory drive can attenuate various reflex responses to airway stimulation, whether CO2 exerts a similar inhibitory effect on nasal reflexes has not been examined. In the present study we studied changes in respiration and circulation during nasal insufflation of isoflurane, a mildly-pungent volatile anesthetic, at a resting level of PetCO2 and at an elevated level of PetCO2 m lightly-anesthetized humans.
KeywordsNasal Mucosa Reflex Response Volatile Anesthetic Respiratory Response Circulatory Response
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